IoT Based Health Machine for COVID-19

The new Corona Virus (COVID-19) is a pandemic of unthinkable scope and magnitude that is posing a significant threat to the medical business worldwide in the twenty-first century. To a greater extent, it has fundamentally altered the texture of life. The growing number of people dying as a result of sickness has instilled fear in the minds of many who are hesitant to seek even basic medical help. And, in light of the recent COVID-19 scenario and the growing number of affected people, researchers began to focus on ways to communicate and monitor patient information remotely in order to reduce the risk of getting infected. The Internet of Things (IoT) is one of the booming technologies in the medical and industrial fields. Patients could benefit from the proposed device because it can monitor and diagnose their health status. This study describes a gadget that measures and records heart rate, body temperature, and CT imaging. These records will be measured and sent to the cloud server using an Arduino device with sensors. © 2022 IEEE.

Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones.

Herein, acetic acid mediated multicomponent synthesis of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-one (2,4-dimethoxy-THPQs) was reported. Single-crystal XRD analysis of four newly developed crystals of 2,4-dimethoxy-THPQs and their DFT study were also reported. The structure of all molecules was optimized using DFT B3LYP/6-31G(d) level and compared with the corresponding single-crystal XRD data. As a result, the theoretical and experimental geometrical parameters (bond lengths and bond angles) were found to be in good agreement. Frontier molecular orbital (FMO) and molecule electrostatic potential (MEP) analyses were used to investigate the physicochemical properties and relative reactivity of 2,4-dimethoxy-THPQs. The formation of strong C-H⋯O and N-H⋯O interaction was investigated by Hirshfeld analysis. Furthermore, electronic charge density concentration in 2,4-dimethoxy-THPQs was analysed by the Mulliken atomic charges which helps to predict the ability of 2,4-dimethoxy-THPQs to bind in the receptor. The molecular docking of the crystal structure of 2,4-dimethoxy-THPQs in the main protease (Mpro) of SARS-CoV-2 suggested that all four 2,4-dimethoxy-THPQs efficiently docked in Mpro. Furthermore, 2,4-dimethoxy-THPQs with a 3-chloro substitution in the phenyl ring have the highest binding affinity because of the additional formation of halogen bonds and highest dipole moment.